Literature DB >> 12202984

Transmission of Y chromosomal microdeletions from father to son through intracytoplasmic sperm injection.

Shinji Komori1, Hiroshi Kato, Shin-ichiro Kobayashi, Koji Koyama, Shinzo Isojima.   

Abstract

We conducted chromosomal analysis of three male infants fathered by severe oligozoospermic males with Y chromosomal microdeletions through intracytoplasmic sperm injection (ICSI). Two of the infants had the same Y chromosomal microdeletions as their fathers. The third infant also had a Y chromosomal microdeletion, which was longer than that found in his father. The results confirm that Y chromosomal microdeletions are transmitted from a father to a son via ICSI and also suggest that the microdeletions may be expanded during such transmission. Genetic counseling for infertile couples contemplating ICSI is important if the male carries Y chromosomal microdeletions.

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Year:  2002        PMID： 12202984     DOI： 10.1007/s100380200066

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  6 in total

1.  Incidence of Y chromosome microdeletions in patients with Klinefelter syndrome.

Authors:  F Sciarra; M Pelloni; F Faja; F Pallotti; G Martino; A F Radicioni; A Lenzi; F Lombardo; D Paoli
Journal:  J Endocrinol Invest       Date:  2018-11-29       Impact factor: 4.256

Review 2.  Y chromosome azoospermia factor region microdeletions and transmission characteristics in azoospermic and severe oligozoospermic patients.

Authors:  Xiao-Wei Yu; Zhen-Tong Wei; Yu-Ting Jiang; Song-Ling Zhang
Journal:  Int J Clin Exp Med       Date:  2015-09-15

3.  Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm.

Authors:  Xiao-hong Liu; Jie Qiao; Rong Li; Li-ying Yan; Li-xue Chen
Journal:  J Assist Reprod Genet       Date:  2013-05-30       Impact factor: 3.412

4.  Y chromosome microdeletions in infertile men with idiopathic oligo- or azoospermia.

Authors:  Ali Hellani; Saad Al-Hassan; Muhammed A Iqbal; Serdar Coskun
Journal:  J Exp Clin Assist Reprod       Date:  2006-01-30

5.  Prevalence of chromosomal abnormalities and Y chromosome microdeletion among men with severe semen abnormalities and its correlation with successful sperm retrieval.

Authors:  Mariano Mascarenhas; Sumi Thomas; Mohan S Kamath; Ramya Ramalingam; Ann Marie Kongari; S Yuvarani; Vivi M Srivastava; Korula George
Journal:  J Hum Reprod Sci       Date:  2016 Jul-Sep

Review 6.  A comprehensive review of genetics and genetic testing in azoospermia.

Authors:  Alaa J Hamada; Sandro C Esteves; Ashok Agarwal
Journal:  Clinics (Sao Paulo)       Date:  2013       Impact factor: 2.365
  6 in total

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