Literature DB >> 12201721

Intramolecular cyclization of acyl radicals onto the azido group: a new radical approach to cyclized lactams.

Luisa Benati1, Rino Leardini, Matteo Minozzi, Daniele Nanni, Piero Spagnolo, Samantha Strazzari, Giuseppe Zanardi.   

Abstract

[reaction: see text] Aryl- and alkyl-derived azidoacyl radicals, generated from thiolesters by intramolecular homolytic substitution at the sulfur, can undergo five- and six-membered cyclization onto the azido moiety to give cyclized lactams.

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Year:  2002        PMID: 12201721     DOI: 10.1021/ol026366t

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  A construction of 4,4-spirocyclic γ-lactams by tandem radical cyclization with carbon monoxide.

Authors:  Mitsuhiro Ueda; Yoshitaka Uenoyama; Nozomi Terasoma; Shoko Doi; Shoji Kobayashi; Ilhyong Ryu; John A Murphy
Journal:  Beilstein J Org Chem       Date:  2013-07-05       Impact factor: 2.883

  1 in total

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