Literature DB >> 12200681

Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes.

D Ribatti1, G Polimeno, A Vacca, A Marzullo, E Crivellato, B Nico, G Lucarelli, F Dammacco.   

Abstract

Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and MC expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.

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Year:  2002        PMID： 12200681     DOI： 10.1038/sj.leu.2402586

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  10 in total

1.  A comparative study of the spatial distribution of mast cells and microvessels in the foetal, adult human thymus and thymoma.

Authors:  Marius Raica; Anca Maria Cimpean; Beatrice Nico; Diego Guidolin; Domenico Ribatti
Journal:  Int J Exp Pathol       Date:  2009-12-04       Impact factor: 1.925

2.  Spatial distribution of mast cells around vessels and glands in human gastric carcinoma.

Authors:  Diego Guidolin; Simona Ruggieri; Tiziana Annese; Cinzia Tortorella; Andrea Marzullo; Domenico Ribatti
Journal:  Clin Exp Med       Date:  2017-01-19       Impact factor: 3.984

3.  Mast cells and angiogenesis in gastric carcinoma.

Authors:  Domenico Ribatti; Diego Guidolin; Andrea Marzullo; Beatrice Nico; Tiziana Annese; Vincenzo Benagiano; Enrico Crivellato
Journal:  Int J Exp Pathol       Date:  2010-04-20       Impact factor: 1.925

Review 4.  Possible biological and translational significance of mast cells density in colorectal cancer.

Authors:  Ilaria Marech; Michele Ammendola; Claudia Gadaleta; Nicola Zizzo; Caroline Oakley; Cosmo Damiano Gadaleta; Girolamo Ranieri
Journal:  World J Gastroenterol       Date:  2014-07-21       Impact factor: 5.742

5.  Non-random spatial relationships between mast cells and microvessels in human endometrial carcinoma.

Authors:  Diego Guidolin; Christian Marinaccio; Cinzia Tortorella; Tiziana Annese; Simona Ruggieri; Nicoletta Finato; Enrico Crivellato; Domenico Ribatti
Journal:  Clin Exp Med       Date:  2016-02-17       Impact factor: 3.984

6.  Tryptase serum levels in patients suffering from hepatocellular carcinoma undergoing intra-arterial chemoembolization: Possible predictive role of response to treatment.

Authors:  Veronica Goffredo; Cosmo Damiano Gadaleta; Annamaria Laterza; Angelo Vacca; Girolamo Ranieri
Journal:  Mol Clin Oncol       Date:  2013-01-03

Review 7.  Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy.

Authors:  Michele Ammendola; Christian Leporini; Ilaria Marech; Cosmo Damiano Gadaleta; Giovanni Scognamillo; Rosario Sacco; Giuseppe Sammarco; Giovambattista De Sarro; Emilio Russo; Girolamo Ranieri
Journal:  Biomed Res Int       Date:  2014-09-11       Impact factor: 3.411

Review 8.  Immune cells and angiogenesis.

Authors:  Domenico Ribatti; Enrico Crivellato
Journal:  J Cell Mol Med       Date:  2009-06-16       Impact factor: 5.310

9.  Colorectal cancer-promoting activity of the senescent peritoneal mesothelium.

Authors:  Justyna Mikuła-Pietrasik; Patrycja Sosińska; Konstantin Maksin; Mał Gorzata Kucińska; Hanna Piotrowska; Marek Murias; Aldona Woźniak; Dariusz Szpurek; Krzysztof Książek
Journal:  Oncotarget       Date:  2015-10-06

10.  Increased number of mast cells in the bone marrow of chronic myeloid leukemia may herald the pending myeloid transformation-the mast cell is an indicator of myeloid transformation.

Authors:  Peipei Xu; Cuiling Zhang; Yushan Wang; Hongyan Wu; Shuwen Cheng; Xiangshan Fan; Qiguo Zhang
Journal:  Transl Cancer Res       Date:  2019-09       Impact factor: 1.241
  10 in total

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