| Literature DB >> 12199980 |
Joan Llevadot1, Takayuki Asahara.
Abstract
Statins promote the proliferation, migration, and survival of endothelial cells and bone marrow-derived endothelial progenitor cells (angioblasts) by stimulating the serine/threonine protein kinase Akt (also known as protein kinase B) pathway. Like vascular endothelial growth factor (VEGF), the statins promote angiogenesis and vasculogenesis. Therefore, Akt activation may explain some of the beneficial effects of the statins, including postnatal neovascularization.Entities:
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Year: 2002 PMID： 12199980 DOI： 10.1016/s0300-8932(02)76713-4
Source DB: PubMed Journal: Rev Esp Cardiol ISSN： 0300-8932 Impact factor: 4.753