Analysis of an adaptive strain estimation technique in elastography.

Elastography is based on the estimation of strain due to tissue compression or expansion. Conventional elastography involves computing strain as the gradient of the displacement (time-delay) estimates between gated pre- and postcompression signals. Uniform temporal stretching of the postcompression signals has been used to reduce the echo-signal decorrelation noise. However, a uniform stretch of the entire postcompression signal is not optimal in the presence of strain contrast in the tissue and could result in loss of contrast in the elastogram. This has prompted the use of local adaptive stretching techniques. Several adaptive strain estimation techniques using wavelets, local stretching and iterative strain estimation have been proposed. Yet, a quantitative analysis of the improvement in quality of the strain estimates overconventional strain estimation techniques has not been reported. We propose a two-stage adaptive strain estimation technique and perform a quantitative comparison with the conventional strain estimation techniques in elastography. In this technique, initial displacement and strain estimates using global stretching are computed, filtered and then used to locally shift and stretch the postcompression signal. This is followed by a correlation of the shifted and stretched postcompression signal with the precompression signal to estimate the local displacements and hence the local strains. As proof of principle, this adaptive stretching technique was tested using simulated and experimental data.