Questionnaire assessment of nonoccupational pesticide exposure in epidemiologic studies of cancer.

Pesticides have been examined in epidemiologic studies as environmental risk factors for cancer, in part, due to the identification of carcinogenic properties of some of these chemicals using animal models. Although the majority of these epidemiologic studies have focused on occupational pesticide exposure, nonoccupational pesticide exposure has also been investigated. The objective of this paper is to review the methodological issues of nonoccupational pesticide exposure assessment, including identifying the methods that have been used to assess self-reported nonoccupational pesticide exposure in epidemiologic studies of cancer, and discussing the strengths and limitations of the current methodology as well as possible enhancements that could be incorporated into future investigations. Issues of exposure assessment that will be reviewed include specificity, recall, and characteristics of pesticide exposure. Additionally, sources of nonoccupational pesticide exposure other than residential will be briefly reviewed.