OBJECTIVE: To test the hypothesis that chronic fatigue syndrome (CFS) is associated with altered cerebral metabolites in the frontal and occipital cortices. METHOD: Cerebral proton magnetic resonance spectroscopy (1H MRS) was carried out in eight CFS patients and eight age- and sex-matched healthy control subjects. Spectra were obtained from 20 x 20 x 20 mm3 voxels in the dominant motor and occipital cortices using a point-resolved spectroscopy pulse sequence. RESULTS: The mean ratio of choline (Cho) to creatine (Cr) in the occipital cortex in CFS (0.97) was significantly higher than in the controls (0.76; P=0.008). No other metabolite ratios were significantly different between the two groups in either the frontal or occipital cortex. In addition, there was a loss of the normal spatial variation of Cho in CFS. CONCLUSION: Our results suggest that there may be an abnormality of phospholipid metabolism in the brain in CFS.
OBJECTIVE: To test the hypothesis that chronic fatigue syndrome (CFS) is associated with altered cerebral metabolites in the frontal and occipital cortices. METHOD: Cerebral proton magnetic resonance spectroscopy (1H MRS) was carried out in eight CFS patients and eight age- and sex-matched healthy control subjects. Spectra were obtained from 20 x 20 x 20 mm3 voxels in the dominant motor and occipital cortices using a point-resolved spectroscopy pulse sequence. RESULTS: The mean ratio of choline (Cho) to creatine (Cr) in the occipital cortex in CFS (0.97) was significantly higher than in the controls (0.76; P=0.008). No other metabolite ratios were significantly different between the two groups in either the frontal or occipital cortex. In addition, there was a loss of the normal spatial variation of Cho in CFS. CONCLUSION: Our results suggest that there may be an abnormality of phospholipid metabolism in the brain in CFS.
Authors: Landrew S Sevel; Jeff Boissoneault; Janelle E Letzen; Michael E Robinson; Roland Staud Journal: Exp Brain Res Date: 2018-05-30 Impact factor: 1.972
Authors: B K Puri; P M Jakeman; M Agour; K D R Gunatilake; K A C Fernando; A I Gurusinghe; I H Treasaden; A D Waldman; P Gishen Journal: Br J Radiol Date: 2011-11-29 Impact factor: 3.039
Authors: Marieke E van Der Schaaf; Iris C Schmits; Megan Roerink; Dirk E M Geurts; Ivan Toni; Karin Roelofs; Floris P De Lange; Urs M Nater; Jos W M van der Meer; Hans Knoop Journal: BMC Psychiatry Date: 2015-07-03 Impact factor: 3.630
Authors: Christina Mueller; Joanne C Lin; Sulaiman Sheriff; Andrew A Maudsley; Jarred W Younger Journal: Brain Imaging Behav Date: 2020-04 Impact factor: 3.978