G Parker1. 1. School of Psychiatry, University of New South Wales, and Mood Disorders Unit, Prince of Wales Hospital, Sydney, Australia. g.parker@unsw.edu.au
Abstract
OBJECTIVE: A possible mechanism whereby the serotonin reuptake inhibitor (SSRI) antidepressants may not (overall) be as effective as the tricyclic (TCA) antidepressants is explored. METHOD: Clinical psychiatrists rated the effectiveness of past antidepressant medications in a clinical panel study of patients with a major depressive disorder, with 200 having previously received a TCA and 219 an SSRI. RESULTS: Analyses indicated decreased SSRI effectiveness with age in those with the melancholic subtype. TCA effectiveness appeared uninfluenced by age and depressive subtype. CONCLUSION: Findings suggest why the broader-based TCAs may be more effective than the SSRIs in implicating age and depressive subtype influences. Copyright Blackwell Munksgaard 2002.
OBJECTIVE: A possible mechanism whereby the serotonin reuptake inhibitor (SSRI) antidepressants may not (overall) be as effective as the tricyclic (TCA) antidepressants is explored. METHOD: Clinical psychiatrists rated the effectiveness of past antidepressant medications in a clinical panel study of patients with a major depressive disorder, with 200 having previously received a TCA and 219 an SSRI. RESULTS: Analyses indicated decreased SSRI effectiveness with age in those with the melancholic subtype. TCA effectiveness appeared uninfluenced by age and depressive subtype. CONCLUSION: Findings suggest why the broader-based TCAs may be more effective than the SSRIs in implicating age and depressive subtype influences. Copyright Blackwell Munksgaard 2002.
Authors: Kristin Köhler-Forsberg; Brice Ozenne; Søren V Larsen; Asbjørn S Poulsen; Elizabeth B Landman; Vibeke H Dam; Cheng-Teng Ip; Anders Jørgensen; Claus Svarer; Gitte M Knudsen; Vibe G Frokjaer; Martin B Jørgensen Journal: Transl Psychiatry Date: 2022-07-11 Impact factor: 7.989