BACKGROUND: Helicobacter pylori infection has been associated with growth restriction in young children. AIM: To determine whether there is an association between H. pylori infection and intrauterine growth restriction. METHODS: Four hundred and forty-eight consecutive pregnant women (aged 15-44 years), attending for routine examinations in the third trimester, were enrolled. Clinical, demographic and previous obstetric data, as well as smoking history, were collected. At delivery, the weight, height, gender and status of the neonate were recorded; intrauterine growth restriction was defined if the birth weight was below the 10th percentile according to the gestational age for infants born in Australia. RESULTS: Eighty-nine (20%) women were seropositive for H. pylori. The prevalence of H. pylori was significantly lower in Caucasians (17%) vs. non-Caucasians (42%, P < 0.0001). There were 34 (7.5%) cases of intrauterine growth restriction (7% Caucasians, 16% Asians, 12% Aborigines and 0% Pacific Islanders). Intrauterine growth restriction was more common in H. pylori-seropositive women than in H. pylori-seronegative women [13.5% vs. 6%; odds ratio (OR) = 2.41; 95% confidence interval (CI), 1.14-5.08; P = 0.018]. A multiple logistic regression model revealed that smoking (OR = 3.55; 95% CI, 1.62-7.79; P = 0.002), maternal height (OR = 0.48; 95% CI, 0.28-0.80; P = 0.005) and H. pylori seropositivity (OR = 2.59; 95% CI, 1.12-5.95; P = 0.025) were all independent risk factors for intrauterine growth restriction. CONCLUSIONS: H. pylori infection in pregnant women may affect foetal intrauterine growth.
BACKGROUND:Helicobacter pylori infection has been associated with growth restriction in young children. AIM: To determine whether there is an association between H. pyloriinfection and intrauterine growth restriction. METHODS: Four hundred and forty-eight consecutive pregnant women (aged 15-44 years), attending for routine examinations in the third trimester, were enrolled. Clinical, demographic and previous obstetric data, as well as smoking history, were collected. At delivery, the weight, height, gender and status of the neonate were recorded; intrauterine growth restriction was defined if the birth weight was below the 10th percentile according to the gestational age for infants born in Australia. RESULTS: Eighty-nine (20%) women were seropositive for H. pylori. The prevalence of H. pylori was significantly lower in Caucasians (17%) vs. non-Caucasians (42%, P < 0.0001). There were 34 (7.5%) cases of intrauterine growth restriction (7% Caucasians, 16% Asians, 12% Aborigines and 0% Pacific Islanders). Intrauterine growth restriction was more common in H. pylori-seropositive women than in H. pylori-seronegative women [13.5% vs. 6%; odds ratio (OR) = 2.41; 95% confidence interval (CI), 1.14-5.08; P = 0.018]. A multiple logistic regression model revealed that smoking (OR = 3.55; 95% CI, 1.62-7.79; P = 0.002), maternal height (OR = 0.48; 95% CI, 0.28-0.80; P = 0.005) and H. pylori seropositivity (OR = 2.59; 95% CI, 1.12-5.95; P = 0.025) were all independent risk factors for intrauterine growth restriction. CONCLUSIONS:H. pyloriinfection in pregnant women may affect foetal intrauterine growth.
Authors: Daniel B DiGiulio; Maria Teresa Gervasi; Roberto Romero; Edi Vaisbuch; Shali Mazaki-Tovi; Juan Pedro Kusanovic; Kimberley S Seok; Ricardo Gómez; Pooja Mittal; Francesca Gotsch; Tinnakorn Chaiworapongsa; Enrique Oyarzún; Chong Jai Kim; David A Relman Journal: J Perinat Med Date: 2010-09 Impact factor: 1.901
Authors: Wouter J den Hollander; Sarah Schalekamp-Timmermans; I Lisanne Holster; Vincent W Jaddoe; Albert Hofman; Henriëtte A Moll; Guillermo I Perez-Perez; Martin J Blaser; Eric A P Steegers; Ernst J Kuipers Journal: Helicobacter Date: 2016-10-27 Impact factor: 5.753
Authors: W J den Hollander; A M M Sonnenschein-van der Voort; I L Holster; J C de Jongste; V W Jaddoe; A Hofman; G I Perez-Perez; H A Moll; M J Blaser; L Duijts; E J Kuipers Journal: Aliment Pharmacol Ther Date: 2016-03-01 Impact factor: 8.171
Authors: Masomeh Hajishafiha; Mohammad Ghasemi-Rad; Aishe Memari; Siamak Naji; Nikol Mladkova; Vida Saeedi Journal: Int J Womens Health Date: 2011-10-05