Literature DB >> 12196936

BNAs: novel nucleic acid analogs with a bridged sugar moiety.

Takeshi Imanishi1, Satoshi Obika.   

Abstract

This article deals with our recent studies on the synthesis of BNAs (Bridged Nucleic Acids), novel nucleic acid analogs bearing a preorganized sugar conformation by a bridged structure. Duplex- and triplex-forming abilities of the BNA modified oligonucleotides are also described.

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Year:  2002        PMID： 12196936     DOI： 10.1039/b201557a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid.

Authors:  Pradeep S Pallan; Jinghua Yu; Charles R Allerson; Eric E Swayze; Punit Seth; Martin Egli
Journal:  Biochemistry       Date:  2011-12-29       Impact factor: 3.162

2.  N,3'-cyclo-5'-O-Cyano-methyl-thymidine.

Authors:  Jingbo Sun; Kun Yang; Ronghui Duan; Jinchang Wu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-29

3.  PCR-Based Rapid Identification System Using Bridged Nucleic Acids for Detection of Clarithromycin-Resistant Mycobacterium avium-M. intracellulare Complex Isolates.

Authors:  Takashi Hirama; Ayako Shiono; Hiroshi Egashira; Etsuko Kishi; Koichi Hagiwara; Hidetoshi Nakamura; Minoru Kanazawa; Makoto Nagata
Journal:  J Clin Microbiol       Date:  2016-01-06       Impact factor: 5.948

4.  Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA.

Authors:  Damian Ittig; Songkai Liu; Dorte Renneberg; Daniel Schümperli; Christian J Leumann
Journal:  Nucleic Acids Res       Date:  2004-01-15       Impact factor: 16.971

5.  Synthesis and physical and physiological properties of 4'-thioRNA: application to post-modification of RNA aptamer toward NF-kappaB.

Authors:  Shuichi Hoshika; Noriaki Minakawa; Akira Matsuda
Journal:  Nucleic Acids Res       Date:  2004-07-19       Impact factor: 16.971

Review 6.  DNA triple helices: biological consequences and therapeutic potential.

Authors:  Aklank Jain; Guliang Wang; Karen M Vasquez
Journal:  Biochimie       Date:  2008-02-21       Impact factor: 4.079

7.  Locked nucleic acid and aptamers.

Authors:  Kasper K Karlsen; Jesper Wengel
Journal:  Nucleic Acid Ther       Date:  2012-12       Impact factor: 5.486

8.  Superior Silencing by 2',4'-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors.

Authors:  Tsuyoshi Yamamoto; Hidenori Yasuhara; Fumito Wada; Mariko Harada-Shiba; Takeshi Imanishi; Satoshi Obika
Journal:  J Nucleic Acids       Date:  2012-09-26

Review 9.  Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry.

Authors:  Dagmara Baraniak; Jerzy Boryski
Journal:  Biomedicines       Date:  2021-05-31

10.  Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo.

Authors:  Shunsuke Wada; Satoshi Obika; Masa-Aki Shibata; Tsuyoshi Yamamoto; Moeka Nakatani; Tetsuji Yamaoka; Hidetaka Torigoe; Mariko Harada-Shiba
Journal:  Mol Ther Nucleic Acids       Date:  2012-09-18       Impact factor: 10.183
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