[Study of acebutolol dialysis and pharmacokinetic data in patients with renal insufficiency undergoing hemodialysis].

The dialysance of acebutolol, in vitro, has been found to be equal to 87 ml/mn for a blood flow of 200 ml/mn through an artificial kidney; at the same flow rate, that of urea is 136 ml/mn. In subjects with normal renal function, half-life of acebutolol in plasma, after oral administration, is 4.4 +/- 0.6 h; in haemodialysed patients with renal failure, it is very increased; during haemodialysis, it is near normal (mean: 5.9 h in 4 subjects). Authors discuss the meaning of acebutolol dialysance, in vivo, considering a possible protein binding of this drug.