| Literature DB >> 12195435 |
Ryuichi Okamoto1, Tomoharu Yajima, Motomi Yamazaki, Takanori Kanai, Makio Mukai, Shinichiro Okamoto, Yasuo Ikeda, Toshifumi Hibi, Johji Inazawa, Mamoru Watanabe.
Abstract
Studies have shown that bone marrow cells have the potential to differentiate into a variety of cell types. Here we show that bone marrow cells can repopulate the epithelia of the human gastrointestinal tract. Epithelial cells of male donor origin were distributed in every part of the gastrointestinal tract of female bone marrow transplant recipients. Donor-derived epithelial cells substantially repopulated the gastrointestinal tract during epithelial regeneration after graft-versus-host disease or ulcer formation. Regeneration of gastrointestinal epithelia with donor-derived cells in humans shows a potential clinical application of bone marrow-derived cells for repairing severely damaged epithelia, not only in the gastrointestinal tract but also in other tissues.Entities:
Mesh：
Year: 2002 PMID： 12195435 DOI： 10.1038/nm755
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440