| Literature DB >> 12195433 |
Bo Li1, Nansheng Chen, Tao Luo, Yo Otsu, Timothy H Murphy, Lynn A Raymond.
Abstract
A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown--the decline of peak current with repeated, sustained agonist application. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.Entities:
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Year: 2002 PMID： 12195433 DOI： 10.1038/nn912
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884