| Literature DB >> 12195432 |
Ya Ping Wang1, Gabriel Dakubo, Paul Howley, Katrina D Campsall, Chantal J Mazarolle, Sarah A Shiga, Paula M Lewis, Andrew P McMahon, Valerie A Wallace.
Abstract
The adult retina is organized into three cellular layers--an outer photoreceptor, a middle interneuron and an inner retinal ganglion cell (RGC) layer. Although the retinal pigment epithelium (RPE) and Müller cells are important in the establishment and maintenance of this organization, the signals involved are unknown. Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina.Mesh：
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Year: 2002 PMID： 12195432 DOI： 10.1038/nn911
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884