| Literature DB >> 12195358 |
Paul K S Chan1, Ching Wan Lam, Tak Hong Cheung, William W H Li, Keith W K Lo, May Y M Chan, Jo L K Cheung, Li Ying Xu, Augustine F Cheng.
Abstract
A case-control study was conducted on 1986 Hong Kong women to assess the risk of human papillomavirus (HPV) type 16 variants for cervical neoplasia. In total, 255 women were HPV-16 positive and were analyzed for E6 and E7 sequence variation. Two novel substitutions at E6 (T86I and Q116E) and 1 at E7 (R66W) were found. Most HPV-16 variants were of Asian (50.6%) or European (44.3%) lineage, and both lineages showed similar risk associations for high-grade and invasive cervical neoplasia. No increased risk was observed for the subclasses European variant and European 350G, which carry a higher risk for invasive cancer in some Western populations. The E7 N29S substitution, reported to have a higher risk in Korean women, was found equally distributed among normal and various degrees of neoplasia. The epidemiology and risk implication of HPV-16 variant infection in Hong Kong differ markedly from other parts of the world.Entities:
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Year: 2002 PMID： 12195358 DOI： 10.1086/342048
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226