Literature DB >> 12194846

Numb: "Adapting" notch for endocytosis.

Hamed Jafar-Nejad1, Koenraad Norga, Hugo Bellen.   

Abstract

During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell, Berdnik et al. show that Numb recruits alpha-Adaptin and that this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch.

Entities:  

Keywords:  Non-programmatic

Mesh：

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Year:  2002        PMID： 12194846     DOI： 10.1016/s1534-5807(02)00228-9

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  11 in total

1.  Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation.

Authors:  Karthik Arumugam; Melanie C Macnicol; Angus M Macnicol
Journal:  Mol Reprod Dev       Date:  2012-07-09       Impact factor: 2.609

2.  LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo.

Authors:  Ryan C Range; Thomas D Glenn; Esther Miranda; David R McClay
Journal:  Development       Date:  2008-06-11       Impact factor: 6.868

3.  RNA editing in Drosophila melanogaster: New targets and functional consequences.

Authors:  Mark Stapleton; Joseph W Carlson; Susan E Celniker
Journal:  RNA       Date:  2006-10-03       Impact factor: 4.942

4.  Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis.

Authors:  Pengcheng Zhou; Jose Alfaro; Eun Hyuk Chang; Xuesong Zhao; Marimelia Porcionatto; Rosalind A Segal
Journal:  Dev Cell       Date:  2011-05-17       Impact factor: 12.270

5.  SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis.

Authors:  Yunchao Xin; Xiaoling Shang; Xiaoran Sun; Guogang Xu; Yachao Liu; Yanbin Liu
Journal:  Bioengineered       Date:  2022-05       Impact factor: 6.832

6.  Whole transcriptome analysis of the ERα synthetic fragment P295-T311 (ERα17p) identifies specific ERα-isoform (ERα, ERα36)-dependent and -independent actions in breast cancer cells.

Authors:  George Notas; Marilena Kampa; Vassiliki Pelekanou; Maria Troullinaki; Yves Jacquot; Guy Leclercq; Elias Castanas
Journal:  Mol Oncol       Date:  2013-02-20       Impact factor: 6.603

7.  Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.

Authors:  Olga Klezovitch; Tania E Fernandez; Stephen J Tapscott; Valeri Vasioukhin
Journal:  Genes Dev       Date:  2004-03-01       Impact factor: 11.361

8.  Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.

Authors:  George A Kyriazis; Cherine Belal; Meenu Madan; David G Taylor; Jang Wang; Zelan Wei; Jogi V Pattisapu; Sic L Chan
Journal:  J Biol Chem       Date:  2009-12-28       Impact factor: 5.157

Review 9.  It's HIP to be a hub: new trends for old-fashioned proteins.

Authors:  Manuela Vecchi; Pier Paolo Di Fiore
Journal:  J Cell Biol       Date:  2005-07-11       Impact factor: 10.539

10.  How Drosophila melanogaster Forms its Mechanoreceptors.

Authors:  D P Furman; T A Bukharina
Journal:  Curr Genomics       Date:  2008       Impact factor: 2.236
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