Literature DB >> 12193281

Monoclonal antibodies to gonadotropin-releasing hormone (GnRH) inhibit binding of the hormone to its receptor.

Pradnya Gangatirkar1, Sunil Gangadharan, Anita Narendranath, Sushma Nagpal, Dinakar M Salunke, Anjali A Karande.   

Abstract

Monoclonal antibodies (MAbs) specific to gonadotropin-releasing hormone (GnRH) were obtained using different strategies of conjugation of the peptide to carrier protein and immunization. Of several antibodies obtained, two, namely F1D3C5 and E2D2 bound GnRH in solution phase. Though the epitopes corresponding to the two overlapped, there was a one amino acid shift in the core epitope. These two antibodies were characterized with respect to inhibition of GnRH induced responses in rat pituitary cultures and alpha-T3.1 mouse gonadotrope cell line.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12193281     DOI： 10.1089/153685902760213895

Source DB:  PubMed          Journal:  Hybrid Hybridomics        ISSN： 1536-8599


  9 in total

1.  A monoclonal antibody to an abrin chimera recognizing a unique epitope on abrin A chain confers protection from abrin-induced lethality.

Authors:  Meenakshi Sundaram Kumar; Anjali A Karande
Journal:  Hum Vaccin Immunother       Date:  2015-09-17       Impact factor: 3.452

2.  A neutralizing antibody to the a chain of abrin inhibits abrin toxicity both in vitro and in vivo.

Authors:  Kalpana Surendranath; Anjali A Karande
Journal:  Clin Vaccine Immunol       Date:  2008-03-19

3.  Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice.

Authors:  Ulrike Klenke; Carol Taylor-Burds; Susan Wray
Journal:  Endocrinology       Date:  2014-02-24       Impact factor: 4.736

4.  CCDC141 Mutation Identified in Anosmic Hypogonadotropic Hypogonadism (Kallmann Syndrome) Alters GnRH Neuronal Migration.

Authors:  B Ian Hutchins; L Damla Kotan; Carol Taylor-Burds; Yusuf Ozkan; Paul J Cheng; Fatih Gurbuz; Jean D R Tiong; Eda Mengen; Bilgin Yuksel; A Kemal Topaloglu; Susan Wray
Journal:  Endocrinology       Date:  2016-03-25       Impact factor: 4.736

5.  Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1.

Authors:  Nicholas Michael Bashour; Susan Wray
Journal:  Endocrinology       Date:  2012-07-20       Impact factor: 4.736

6.  BPA Directly Decreases GnRH Neuronal Activity via Noncanonical Pathway.

Authors:  Ulrike Klenke; Stephanie Constantin; Susan Wray
Journal:  Endocrinology       Date:  2016-03-02       Impact factor: 4.736

7.  Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.

Authors:  Carol Taylor-Burds; Paul Cheng; Susan Wray
Journal:  PLoS One       Date:  2015-06-25       Impact factor: 3.240

8.  Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway.

Authors:  Leigh Dairaghi; Ellen Flannery; Paolo Giacobini; Aybike Saglam; Hassan Saadi; Stephanie Constantin; Filippo Casoni; Brian W Howell; Susan Wray
Journal:  Front Cell Neurosci       Date:  2018-08-03       Impact factor: 5.505

9.  Monoclonal antibodies against Hepatitis C genotype 3a virus like particle inhibit virus entry in cell culture system.

Authors:  Soma Das; Rohini K Shetty; Anuj Kumar; Radhika Nagamangalam Shridharan; Ranjitha Tatineni; Giriprakash Chi; Anirban Mukherjee; Saumitra Das; Shaila Melkote Subbarao; Anjali Anoop Karande
Journal:  PLoS One       Date:  2013-01-15       Impact factor: 3.240
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.