Literature DB >> 12193022

Novel cytotoxic oxygenated C29 sterols from the Colombian marine sponge Polymastia tenax.

Gilmar Santafé1, Vanessa Paz, Jaime Rodríguez, Carlos Jiménez.   

Abstract

Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. Compounds 1 and 2 showed antiproliferative activity toward A-549, HT-29, H-116, MS-1, and PC-3 tumor cells in the range 0.5-10 microg/mL.

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Year:  2002        PMID： 12193022     DOI： 10.1021/np0200459

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Isolation and structure elucidation of azoricasterol, a new sterol of the deepwater sponge Macandrewia azorica.

Authors:  Harald Gross; Joachim Reitner; Gabriele M König
Journal:  Naturwissenschaften       Date:  2004-09-01

2.  Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies.

Authors:  Libin Xu; Zeljka Korade; Ned A Porter
Journal:  J Am Chem Soc       Date:  2010-02-24       Impact factor: 15.419

3.  Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture.

Authors:  Mario Luiz Conte da Frota; Elizandra Braganhol; Andrés Delgado Canedo; Fabio Klamt; Miriam Anders Apel; Beatriz Mothes; Cléa Lerner; Ana Maria Oliveira Battastini; Amélia Teresinha Henriques; José Cláudio Fonseca Moreira
Journal:  Invest New Drugs       Date:  2008-05-03       Impact factor: 3.850

4.  Extracts of marine sponge Polymastia janeirensis induce oxidative cell death through a caspase-9 apoptotic pathway in human U138MG glioma cell line.

Authors:  Mario Luiz Conte da Frota; Elizandra Braganhol; Andrés Delgado Canedo; Fabio Klamt; Miriam Anders Apel; Beatriz Mothes; Cléa Lerner; Ana Maria Oliveira Battastini; Amélia Teresinha Henriques; José Cláudio Fonseca Moreira
Journal:  Invest New Drugs       Date:  2008-11-11       Impact factor: 3.850

5.  Growth inhibition of human gynecologic and colon cancer cells by Phyllanthus watsonii through apoptosis induction.

Authors:  Sujatha Ramasamy; Norhanom Abdul Wahab; Nurhayati Zainal Abidin; Sugumaran Manickam; Zubaidah Zakaria
Journal:  PLoS One       Date:  2012-04-20       Impact factor: 3.240

6.  In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa.

Authors:  Dawrin Pech-Puch; Mar Pérez-Povedano; Marta Martinez-Guitian; Cristina Lasarte-Monterrubio; Juan Carlos Vázquez-Ucha; Germán Bou; Jaime Rodríguez; Alejandro Beceiro; Carlos Jimenez
Journal:  Mar Drugs       Date:  2020-06-23       Impact factor: 5.118

Review 7.  Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.

Authors:  Mohammad Ferdous Mehbub; Jie Lei; Christopher Franco; Wei Zhang
Journal:  Mar Drugs       Date:  2014-08-19       Impact factor: 5.118

8.  Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis.

Authors:  Larisa K Shubina; Tatyana N Makarieva; Vladimir A Denisenko; Roman S Popov; Sergey A Dyshlovoy; Boris B Grebnev; Pavel S Dmitrenok; Gunhild von Amsberg; Valentin A Stonik
Journal:  Mar Drugs       Date:  2020-08-30       Impact factor: 5.118
  8 in total

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