Literature DB >> 12192155

Effective isolation of magnesium lithospermate B and its inhibition of aldose reductase and fibronectin on mesangial cell line.

Mankil Jung1, Hyun Chul Lee, Chul Woo Ahn, Whuijung Park, Sunhee Choi, Hanjo Kim, Donghak Cho, Geun Taek Lee, Hai-Ri Li.   

Abstract

We developed an effective isolation method of magnesium lithospermate B from Salviae miltiorrhizae Radix and found for the first time that magnesium lithospermate B shows strong in vitro inhibition (IC50=0.04 microM) of aldose reductase (AR), 2.5 times than that of clinically used epalrestat (IC50=0.1 microM) and accumulation of fibronectin dose dependently.

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Year:  2002        PMID： 12192155     DOI： 10.1248/cpb.50.1135

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

1.  Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats.

Authors:  Yong Han Paik; Young Joon Yoon; Hyun Chul Lee; Man Kil Jung; So Hee Kang; Sook In Chung; Ja Kyung Kim; Jae Yong Cho; Kwan Sik Lee; Kwang Hyub Han
Journal:  Exp Mol Med       Date:  2011-06-30       Impact factor: 8.718

2.  Protective effects of Salvianolic acid B on Schwann cells apoptosis induced by high glucose.

Authors:  Lian-Qing Sun; Jue Zhao; Ting-Ting Zhang; Ling Qu; Xuan Wang; Bing Xue; Xiao-Jin Li; Yi-Ming Mu; Ju-Ming Lu
Journal:  Neurochem Res       Date:  2012-01-18       Impact factor: 3.996

3.  Genetic diversity and population structure of Salvia miltiorrhiza Bge in China revealed by ISSR and SRAP.

Authors:  Zhenqiao Song; Xingfeng Li; Honggang Wang; Jianhua Wang
Journal:  Genetica       Date:  2009-10-21       Impact factor: 1.082

4.  Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.

Authors:  Mengyang Liu; Quan Pan; Yuanli Chen; Xiaoxiao Yang; Buchang Zhao; Lifu Jia; Yan Zhu; Boli Zhang; Xiumei Gao; Xiaoju Li; Jihong Han; Yajun Duan
Journal:  Sci Rep       Date:  2015-06-10       Impact factor: 4.379

5.  The effect of lithospermic acid, an antioxidant, on development of diabetic retinopathy in spontaneously obese diabetic rats.

Authors:  Cheng Ji Jin; Sung Hoon Yu; Xiao-Mei Wang; Se Joon Woo; Hyo Jin Park; Hyun Chul Lee; Sung Hee Choi; Kyoung Min Kim; Jung Hee Kim; Kyong Soo Park; Hak Chul Jang; Soo Lim
Journal:  PLoS One       Date:  2014-06-06       Impact factor: 3.240

6.  Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats.

Authors:  Lixia Ji; Lixia Cheng; Zhihong Yang
Journal:  J Diabetes Res       Date:  2017-09-05       Impact factor: 4.011

7.  Synthesis of a dual-labeled probe of dimethyl lithospermate B with photochemical and fluorescent properties.

Authors:  Eunyoung Lim; Jeremy Ricci; Mankil Jung
Journal:  Molecules       Date:  2011-11-28       Impact factor: 4.411
  7 in total

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