Literature DB >> 12192135

New farnesane-type sesquiterpenes, hedychiols A and B 8,9-diacetate, and inhibitors of degranulation in RBL-2H3 cells from the rhizome of Hedychium coronarium.

Toshio Morikawa1, Hisashi Matsuda, Yasuko Sakamoto, Kazuho Ueda, Masayuki Yoshikawa.   

Abstract

Two new farnesane-type sesquiterpenes, hedychiols A and B 8,9-diacetate, were isolated from the methanolic extract of the fresh rhizome of Hedychium coronarium KOEN. cultivated in Japan. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of isolated constituents on the release of beta-hexosaminidase from RBL-2H3 cells were examined, and hedychilactone A and coronarin D were found to show the inhibitory activity.

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Year:  2002        PMID： 12192135     DOI： 10.1248/cpb.50.1045

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  6 in total

1.  Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells.

Authors:  Toshio Morikawa; Ikuko Hachiman; Kiyofumi Ninomiya; Hiroki Hata; Kaoru Sugawara; Osamu Muraoka; Hisashi Matsuda
Journal:  J Nat Med       Date:  2018-01-15       Impact factor: 2.343

2.  New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium.

Authors:  Jih-Jung Chen; Chia-Wei Ting; Yi-Chin Wu; Tsong-Long Hwang; Ming-Jen Cheng; Ping-Jyun Sung; Tai-Chi Wang; Jinn-Fen Chen
Journal:  Int J Mol Sci       Date:  2013-06-25       Impact factor: 5.923

3.  Coronarin D induces reactive oxygen species-mediated cell death in human nasopharyngeal cancer cells through inhibition of p38 MAPK and activation of JNK.

Authors:  Jui-Chieh Chen; Ming-Chang Hsieh; Shu-Hui Lin; Chia-Chieh Lin; Yi-Ting Hsi; Yu-Sheng Lo; Yi-Ching Chuang; Ming-Ju Hsieh; Mu-Kuan Chen
Journal:  Oncotarget       Date:  2017-11-14

4.  Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line.

Authors:  Yollanda E M Franco; Marcia Y Okubo; Adriana D Torre; Paula P Paiva; Marcela N Rosa; Viviane A O Silva; Rui M Reis; Ana L T G Ruiz; Paulo M Imamura; João E de Carvalho; Giovanna B Longato
Journal:  Molecules       Date:  2019-12-09       Impact factor: 4.411

5.  Coronarin D, a Metabolite from the Wild Turmeric, Curcuma aromatica, Promotes the Differentiation of Neural Stem Cells into Astrocytes.

Authors:  Satoshi Otsuka; Midori Kawamura; Shutaro Fujino; Fumiaki Nakamura; Daisuke Arai; Nobuhiro Fusetani; Yoichi Nakao
Journal:  J Agric Food Chem       Date:  2022-03-04       Impact factor: 5.279

Review 6.  The Complexity of Sesquiterpene Chemistry Dictates Its Pleiotropic Biologic Effects on Inflammation.

Authors:  Narcy Arizmendi; Syed Benazir Alam; Khalid Azyat; Darren Makeiff; A Dean Befus; Marianna Kulka
Journal:  Molecules       Date:  2022-04-11       Impact factor: 4.927
  6 in total

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