| Literature DB >> 12191570 |
Nozomi Niitsu1, Masaaki Higashihara, Yoshio Honma.
Abstract
When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. The concentration of IFN-gamma that effectively inhibited the proliferation of BALM-3 cells was 1/40 of that required for BALM-1 cells. STAT-1 phosphorylation, IRF-1 mRNA and protein expression and RAR-beta expression were enhanced to a greater degree in BALM-3 cells treated with IFN-gamma and ATRA than in BALM-1 cells treated with IFN-gamma and ATRA, suggesting that these IFN-gamma related genes were involved in the induction of apoptosis of BALM-3 cells.Entities:
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Year: 2002 PMID： 12191570 DOI： 10.1016/s0145-2126(01)00202-8
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156