Literature DB >> 12191468

Huntingtin fragments that aggregate go their separate ways.

Marian DiFiglia1.   

Abstract

N-terminal region of mutant huntingtin forms intranuclear and cytoplasmic aggregates in neurons that may contribute to neuronal death in Huntington's disease. show that different endoprotease-cleaved huntingtin fragments form nuclear and cytoplasmic inclusions.

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Year:  2002        PMID： 12191468     DOI： 10.1016/s1097-2765(02)00609-3

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  5 in total

Review 1.  PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond.

Authors:  Taiji Tsunemi; Albert R La Spada
Journal:  Prog Neurobiol       Date:  2011-11-09       Impact factor: 11.685

2.  Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

Authors:  Raúl Pardo; Emilie Colin; Etienne Régulier; Patrick Aebischer; Nicole Déglon; Sandrine Humbert; Frédéric Saudou
Journal:  J Neurosci       Date:  2006-02-01       Impact factor: 6.167

3.  Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease.

Authors:  Sonia Podvin; Sara Brin Rosenthal; William Poon; Enlin Wei; Kathleen M Fisch; Vivian Hook
Journal:  J Huntingtons Dis       Date:  2022

4.  Nucleocytoplasmic shuttling activity of ataxin-3.

Authors:  Sandra Macedo-Ribeiro; Luísa Cortes; Patrícia Maciel; Ana Luísa Carvalho
Journal:  PLoS One       Date:  2009-06-08       Impact factor: 3.240

5.  The CFTR-derived peptides as a model of sequence-specific protein aggregation.

Authors:  Daniel Bąk; Garry R Cutting; Michał Milewski
Journal:  Cell Mol Biol Lett       Date:  2007-05-10       Impact factor: 5.787
  5 in total

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