Literature DB >> 12189884

A new approach to functionalized spiropiperidines through tandem RCM and nitrogen-directed reactions.

Andrew S Edwards1, Robert A J Wybrow, Craig Johnstone, Harry Adams, Joseph P A Harrity.   

Abstract

The synthesis of a functionalized spiropiperidine via a tandem ring closing metathesis strategy is described, furthermore, the regio- and stereoselective functionalization of this compound has been achieved through a novel nitrogen-directed epoxidation reaction.

Entities:  

Year:  2002        PMID： 12189884     DOI： 10.1039/b203851j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Recent advances in the application of ring-closing metathesis for the synthesis of unsaturated nitrogen heterocycles.

Authors:  Emilia J Groso; Corinna S Schindler
Journal:  Synthesis (Stuttg)       Date:  2019-02-08       Impact factor: 3.157

2.  Hf(IV)-catalyzed enantioselective epoxidation of N-alkenyl sulfonamides and N-tosyl imines.

Authors:  José Luis Olivares-Romero; Zhi Li; Hisashi Yamamoto
Journal:  J Am Chem Soc       Date:  2012-03-20       Impact factor: 15.419

3.  Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups.

Authors:  Arismel Tena Meza; Thomas Wurm; Lewis Smith; Seung Wook Kim; Jason R Zbieg; Craig E Stivala; Michael J Krische
Journal:  J Am Chem Soc       Date:  2018-01-19       Impact factor: 15.419

4.  Regio- and Diastereoselective Synthesis of Highly Substituted, Oxygenated Piperidines from Tetrahydropyridines.

Authors:  Shuming Chen; Brandon Q Mercado; Robert G Bergman; Jonathan A Ellman
Journal:  J Org Chem       Date:  2015-06-22       Impact factor: 4.354
  4 in total

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