| Literature DB >> 12188646 |
Aaron Wrobleski1, Kiran Sahasrabudhe, Jeffrey Aubé.
Abstract
The dendrobatid alkaloid (-)-251F was synthesized. The key steps of the synthesis were (1) an asymmetric Diels-Alder reaction to establish four of the necessary stereocenters in the target, (2) a ring-opening/ring-closing metathesis reaction to establish a key [3.3.0] bicyclic intermediate, and (3) an intramolecular Schmidt reaction.Entities:
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Year: 2002 PMID： 12188646 DOI： 10.1021/ja027113y
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419