| Literature DB >> 12188388 |
Siripakorn Sangkitporn1, Budsaba Rerkamnuaychoke, Somchai Sangkitporn, Chartchai Mitrakul, Yavamal Sutivigit.
Abstract
Hemoglobin G Makassar was identified in a family of Thai origin, which was found to share identical properties with hemoglobin S in routine hemoglobin separation both by cellulose acetate electrophoresis and cation-exchange HPLC. It is, therefore, subjects with hemoglobin G Makassar and hemoglobin S who may sometimes be mistakenly identified for each other. In this study, identification of hemoglobin G Makassar was achieved by DNA sequence analysis, which revealed a single nucleotide substitution GAG-->GCG at codon 6 of the beta-globin gene. The hemoglobin variant was hemoglobin G Makassar [beta 6:Glu-->Ala]. This is the first report of hemoglobin G Makassar in Thailand.Entities:
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Year: 2002 PMID： 12188388
Source DB: PubMed Journal: J Med Assoc Thai ISSN： 0125-2208