| Literature DB >> 12185668 |
Takaaki Abe1, Takehiro Suzuki, Michiaki Unno, Taro Tokui, Sadayoshi Ito.
Abstract
Thyroid hormones, being hydrophobic, were thought to enter target cell membranes by passive diffusion. However, recent studies have documented the existence of numerous organic anion transport systems, about half of which also transport thyroid hormones into (and possibly out of) a variety of target cells. Several of the genes encoding thyroid hormone transporters have been characterized by means of molecular approaches. Here, we discuss the classification of thyroid hormone transporters, with emphasis on how they are influenced by their ionic milieu and what their symported organic anions are.Mesh:
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Year: 2002 PMID: 12185668 DOI: 10.1016/s1043-2760(02)00599-4
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN: 1043-2760 Impact factor: 12.015