| Literature DB >> 12185596 |
Kenkichi Masutomi1, Shuichi Kaneko, Mami Yasukawa, Kuniaki Arai, Seishi Murakami, Kenichi Kobayashi.
Abstract
Human telomerase reverse transcriptase, hTERT, is the catalytic component of human telomerase. Expression of hTERT confers telomerase activity, indicating that hTERT is the rate-limiting component of human telomerase. Here we report the detection of anti-hTERT auto-antibodies in the sera derived patients with hepatocellular carcinoma using recombinant, purified hTERT as an antigen in an enzyme linked immunosorbent assay (ELISA). The levels of anti-hTERT antibodies in serum correlated with progression to hepatocellular carcinoma. In contrast, we detected only low levels of anti-hTERT auto-antibodies in the sera derived from 18 normal volunteers. The observation of hTERT auto-antibodies in the sera derived from cancer patients suggests that such auto-antibodies constitute novel and specific tumor marker.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12185596 DOI： 10.1038/sj.onc.1205788
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867