Literature DB >> 12183637

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

Gregory A Cope1, Greg S B Suh, L Aravind, Sylvia E Schwarz, S Lawrence Zipursky, Eugene V Koonin, Raymond J Deshaies.   

Abstract

COP9 signalosome (CSN) cleaves the ubiquitin-like protein Nedd8 from the Cul1 subunit of SCF ubiquitin ligases. The Jab1/MPN domain metalloenzyme (JAMM) motif in the Jab1/Csn5 subunit was found to underlie CSN's Nedd8 isopeptidase activity. JAMM is found in proteins from archaea, bacteria, and eukaryotes, including the Rpn11 subunit of the 26S proteasome. Metal chelators and point mutations within JAMM abolished CSN-dependent cleavage of Nedd8 from Cul1, yet had little effect on CSN complex assembly. Optimal SCF activity in yeast and both viability and proper photoreceptor cell (R cell) development in Drosophila melanogaster required an intact Csn5 JAMM domain. We propose that JAMM isopeptidases play important roles in a variety of physiological pathways.

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Year:  2002        PMID： 12183637     DOI： 10.1126/science.1075901

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  288 in total

1.  The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses.

Authors:  Suhua Feng; Ligeng Ma; Xiping Wang; Daoxin Xie; S P Dinesh-Kumar; Ning Wei; Xing Wang Deng
Journal:  Plant Cell       Date:  2003-05       Impact factor: 11.277

2.  Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms.

Authors:  Cong Liu; Kelly A Powell; Kirsten Mundt; LeJung Wu; Antony M Carr; Thomas Caspari
Journal:  Genes Dev       Date:  2003-04-14       Impact factor: 11.361

3.  Crystal structure of human otubain 2.

Authors:  Max H Nanao; Sergey O Tcherniuk; Jadwiga Chroboczek; Otto Dideberg; Andréa Dessen; Maxim Y Balakirev
Journal:  EMBO Rep       Date:  2004-07-16       Impact factor: 8.807

Review 4.  Regulated proteolysis and plant development.

Authors:  Claus Schwechheimer; Katja Schwager
Journal:  Plant Cell Rep       Date:  2004-09-10       Impact factor: 4.570

5.  The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting.

Authors:  Alyson Knowles; Kyunghee Koh; June-Tai Wu; Cheng-Ting Chien; Daniel A Chamovitz; Justin Blau
Journal:  J Neurosci       Date:  2009-01-28       Impact factor: 6.167

Review 6.  Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases.

Authors:  Jeffrey Hannah; Pengbo Zhou
Journal:  DNA Repair (Amst)       Date:  2009-02-23

7.  The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development.

Authors:  Giuliana Gusmaroli; Suhua Feng; Xing Wang Deng
Journal:  Plant Cell       Date:  2004-10-14       Impact factor: 11.277

8.  COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast.

Authors:  Jiong Yan; Katherina Walz; Hisashi Nakamura; Sandra Carattini-Rivera; Qi Zhao; Hannes Vogel; Ning Wei; Monica J Justice; Allan Bradley; James R Lupski
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

9.  Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.

Authors:  Karin Lykke-Andersen; Laura Schaefer; Suchithra Menon; Xing-Wang Deng; Jeffrey Boone Miller; Ning Wei
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

10.  Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells.

Authors:  Pei-Hua Li; Lin Wang; Yao-Jie Pan; Miao-Miao Sang; Jun-Nian Zheng; Dong-Sheng Pei
Journal:  Oncol Lett       Date:  2018-02-06       Impact factor: 2.967
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