Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation.

Literature DB >> 12183584

Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation.

Timothy D Starner¹, W Edward Swords, Michael A Apicella, Paul B McCray.

Abstract

Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human beta-defensin 2 (HBD-2) compared to the wild type. Complementation by htrB in trans to acylation competence reversed this increased sensitivity. In contrast, NTHI was more susceptible to HBD-3 and showed no changes in sensitivity as a result of lipooligosaccharide mutations in oligosaccharide and lipid A biosynthesis genes.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12183584 PMCID： PMC128250 DOI： 10.1128/IAI.70.9.5287-5289.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

26 in total

1. Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor.

Authors: W E Swords; B A Buscher; K Ver Steeg Ii; A Preston; W A Nichols; J N Weiser; B W Gibson; M A Apicella
Journal: Mol Microbiol Date: 2000-07 Impact factor: 3.501

2. The structure of human beta-defensin-2 shows evidence of higher order oligomerization.

Authors: D M Hoover; K R Rajashankar; R Blumenthal; A Puri; J J Oppenheim; O Chertov; J Lubkowski
Journal: J Biol Chem Date: 2000-10-20 Impact factor: 5.157

3. Adaptation of Haemophilus influenzae to acquired and innate humoral immunity based on phase variation of lipopolysaccharide.

Authors: J N Weiser; N Pan
Journal: Mol Microbiol Date: 1998-11 Impact factor: 3.501

4. Discovery of new human beta-defensins using a genomics-based approach.

Authors: H P Jia; B C Schutte; A Schudy; R Linzmeier; J M Guthmiller; G K Johnson; B F Tack; J P Mitros; A Rosenthal; T Ganz; P B McCray
Journal: Gene Date: 2001-01-24 Impact factor: 3.688

5. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa.

Authors: R K Ernst; E C Yi; L Guo; K B Lim; J L Burns; M Hackett; S I Miller
Journal: Science Date: 1999-11-19 Impact factor: 47.728

6. Evaluation of phase variation of nontypeable Haemophilus influenzae lipooligosaccharide during nasopharyngeal colonization and development of otitis media in the chinchilla model.

Authors: H H Tong; L E Blue; M A James; Y P Chen; T F DeMaria
Journal: Infect Immun Date: 2000-08 Impact factor: 3.441

7. Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract.

Authors: E S Lysenko; J Gould; R Bals; J M Wilson; J N Weiser
Journal: Infect Immun Date: 2000-03 Impact factor: 3.441

8. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic.

Authors: J Harder; J Bartels; E Christophers; J M Schroder
Journal: J Biol Chem Date: 2000-11-20 Impact factor: 5.157

9. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.

Authors: J E Jackman; C A Fierke; L N Tumey; M Pirrung; T Uchiyama; S H Tahir; O Hindsgaul; C R Raetz
Journal: J Biol Chem Date: 2000-04-14 Impact factor: 5.157

10. Production of beta-defensins by human airway epithelia.

Authors: P K Singh; H P Jia; K Wiles; J Hesselberth; L Liu; B A Conway; E P Greenberg; E V Valore; M J Welsh; T Ganz; B F Tack; P B McCray
Journal: Proc Natl Acad Sci U S A Date: 1998-12-08 Impact factor: 11.205

37 in total

1. pagP is required for resistance to antibody-mediated complement lysis during Bordetella bronchiseptica respiratory infection.

Authors: Mylisa R Pilione; Elizabeth J Pishko; Andrew Preston; Duncan J Maskell; Eric T Harvill
Journal: Infect Immun Date: 2004-05 Impact factor: 3.441

2. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.

Authors: Kevin M Mason; Robert S Munson; Lauren O Bakaletz
Journal: Infect Immun Date: 2005-01 Impact factor: 3.441

3. Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides.

Authors: Slavena Vylkova; Xuewei S Li; Jennifer C Berner; Mira Edgerton
Journal: Antimicrob Agents Chemother Date: 2006-01 Impact factor: 5.191

9. Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia.

Authors: Audra A Winder; Christine Wohlford-Lenane; Todd E Scheetz; Brie N Nardy; Lori J Manzel; Dwight C Look; Paul B McCray
Journal: Respir Res Date: 2009-10-16

Review 10. Immunopathogenesis of polymicrobial otitis media.

Authors: Lauren O Bakaletz
Journal: J Leukoc Biol Date: 2009-10-20 Impact factor: 4.962