Literature DB >> 12183580

Mixed periodontal Th1-Th2 cytokine profile in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)- mediated alveolar bone destruction in vivo.

Yen-Tung A Teng1.   

Abstract

The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo.

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Year:  2002        PMID： 12183580      PMCID： PMC128282          DOI： 10.1128/IAI.70.9.5269-5273.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  32 in total

Review 1.  The role of dendritic cells in the induction and regulation of immunity to microbial infection.

Authors:  C Reis e Sousa; A Sher; P Kaye
Journal:  Curr Opin Immunol       Date:  1999-08       Impact factor: 7.486

Review 2.  T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal.

Authors:  P Kaliński; C M Hilkens; E A Wierenga; M L Kapsenberg
Journal:  Immunol Today       Date:  1999-12

3.  Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease.

Authors:  T Kawai; R Eisen-Lev; M Seki; J W Eastcott; M E Wilson; M A Taubman
Journal:  J Immunol       Date:  2000-02-15       Impact factor: 5.422

4.  Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing.

Authors:  O Takeichi; J Haber; T Kawai; D J Smith; I Moro; M A Taubman
Journal:  J Dent Res       Date:  2000-08       Impact factor: 6.116

5.  Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection.

Authors:  Y T Teng; H Nguyen; X Gao; Y Y Kong; R M Gorczynski; B Singh; R P Ellen; J M Penninger
Journal:  J Clin Invest       Date:  2000-09       Impact factor: 14.808

6.  Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

Authors:  Y Y Kong; U Feige; I Sarosi; B Bolon; A Tafuri; S Morony; C Capparelli; J Li; R Elliott; S McCabe; T Wong; G Campagnuolo; E Moran; E R Bogoch; G Van; L T Nguyen; P S Ohashi; D L Lacey; E Fish; W J Boyle; J M Penninger
Journal:  Nature       Date:  1999-11-18       Impact factor: 49.962

7.  Periodontal immune responses of human lymphocytes in Actinobacillus actinomycetemcomitans-inoculated NOD/SCID mice engrafted with peripheral blood leukocytes of periodontitis patients.

Authors:  Y T Teng; H Nguyen; A Hassanloo; R P Ellen; N Hozumi; R M Gorczynski
Journal:  J Periodontal Res       Date:  1999-01       Impact factor: 4.419

8.  CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice.

Authors:  P J Baker; M Dixon; R T Evans; L Dufour; E Johnson; D C Roopenian
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

9.  T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

Authors:  H Takayanagi; K Ogasawara; S Hida; T Chiba; S Murata; K Sato; A Takaoka; T Yokochi; H Oda; K Tanaka; K Nakamura; T Taniguchi
Journal:  Nature       Date:  2000-11-30       Impact factor: 49.962

10.  Dental cells express factors that regulate bone resorption.

Authors:  C S Rani; M MacDougall
Journal:  Mol Cell Biol Res Commun       Date:  2000-03
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  11 in total

1.  The cytolethal distending toxin induces receptor activator of NF-kappaB ligand expression in human gingival fibroblasts and periodontal ligament cells.

Authors:  G N Belibasakis; A Johansson; Y Wang; C Chen; S Kalfas; U H Lerner
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

2.  Gamma interferon positively modulates Actinobacillus actinomycetemcomitans-specific RANKL+ CD4+ Th-cell-mediated alveolar bone destruction in vivo.

Authors:  Yen-Tung A Teng; Deeqa Mahamed; Bhagirath Singh
Journal:  Infect Immun       Date:  2005-06       Impact factor: 3.441

Review 3.  Oral mucosal dendritic cells and periodontitis: many sides of the same coin with new twists.

Authors:  Christopher W Cutler; Yen-Tung A Teng
Journal:  Periodontol 2000       Date:  2007       Impact factor: 7.589

4.  Interleukin-10 inhibits gram-negative-microbe-specific human receptor activator of NF-kappaB ligand-positive CD4+-Th1-cell-associated alveolar bone loss in vivo.

Authors:  Xiaoxia Zhang; Yen-Tung A Teng
Journal:  Infect Immun       Date:  2006-08       Impact factor: 3.441

5.  Targeting mRNA stability arrests inflammatory bone loss.

Authors:  Chetan S Patil; Min Liu; Wenpu Zhao; Derek D Coatney; Fei Li; Elizabeth A VanTubergen; Nisha J D'Silva; Keith L Kirkwood
Journal:  Mol Ther       Date:  2008-08-05       Impact factor: 11.454

6.  Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model.

Authors:  Helen C Schreiner; Kathy Sinatra; Jeffrey B Kaplan; David Furgang; Scott C Kachlany; Paul J Planet; Brenda A Perez; David H Figurski; Daniel H Fine
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-19       Impact factor: 11.205

Review 7.  The use of rodent models to investigate host-bacteria interactions related to periodontal diseases.

Authors:  Dana T Graves; Daniel Fine; Yen-Tung A Teng; Thomas E Van Dyke; George Hajishengallis
Journal:  J Clin Periodontol       Date:  2008-02       Impact factor: 8.728

Review 8.  A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17.

Authors:  S L Gaffen; G Hajishengallis
Journal:  J Dent Res       Date:  2008-09       Impact factor: 6.116

9.  B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection.

Authors:  Pamela J Baker; Nicole Ryan Boutaugh; Michaela Tiffany; Derry C Roopenian
Journal:  Interdiscip Perspect Infect Dis       Date:  2009-10-25

Review 10.  Humanized Mouse Models for the Study of Periodontitis: An Opportunity to Elucidate Unresolved Aspects of Its Immunopathogenesis and Analyze New Immunotherapeutic Strategies.

Authors:  Carolina Rojas; Michelle P García; Alan F Polanco; Luis González-Osuna; Alfredo Sierra-Cristancho; Samanta Melgar-Rodríguez; Emilio A Cafferata; Rolando Vernal
Journal:  Front Immunol       Date:  2021-06-17       Impact factor: 7.561
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