Literature DB >> 12183579

Simultaneous expression of different variant-specific surface proteins in single Giardia lamblia trophozoites during encystation.

Pedro G Carranza1, Gisela Feltes, Andrea Ropolo, Silvia M C Quintana, María C Touz, Hugo D Luján.   

Abstract

A novel variant-specific surface protein (VSP) from Giardia was identified using the monoclonal antibody 9B10, raised against purified cyst walls. VSP9B10B is preferentially induced during encystation and expressed simultaneously with other VSPs on the surface of encysting trophozoites. These results support the hypothesis that encystation and antigenic variation are processes that are mechanistically related.

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Year:  2002        PMID： 12183579      PMCID： PMC128263          DOI： 10.1128/IAI.70.9.5265-5268.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  18 in total

1.  Variant-specific surface protein switching in Giardia lamblia.

Authors:  T E Nash; H T Luján; M R Mowatt; J T Conrad
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441

2.  The activity of a developmentally regulated cysteine proteinase is required for cyst wall formation in the primitive eukaryote Giardia lamblia.

Authors:  María C Touz; María J Nores; Ileana Slavin; Carlos Carmona; John T Conrad; Michael R Mowatt; Theodore E Nash; Carlos E Coronel; Hugo D Luján
Journal:  J Biol Chem       Date:  2001-12-28       Impact factor: 5.157

Review 3.  Mechanisms of Giardia lamblia differentiation into cysts.

Authors:  H D Luján; M R Mowatt; T E Nash
Journal:  Microbiol Mol Biol Rev       Date:  1997-09       Impact factor: 11.056

Review 4.  The Giardia lamblia genome.

Authors:  R D Adam
Journal:  Int J Parasitol       Date:  2000-04-10       Impact factor: 3.981

Review 5.  Antigenic variation in Giardia lamblia and the host's immune response.

Authors:  T E Nash
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1997-09-29       Impact factor: 6.237

6.  Cholesterol starvation induces differentiation of the intestinal parasite Giardia lamblia.

Authors:  H D Luján; M R Mowatt; L G Byrd; T E Nash
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

7.  Differentiation-associated surface antigen variation in the ancient eukaryote Giardia lamblia.

Authors:  S G Svärd; T C Meng; M L Hetsko; J M McCaffery; F D Gillin
Journal:  Mol Microbiol       Date:  1998-12       Impact factor: 3.501

8.  Variant surface antigens of Giardia lamblia are associated with the presence of a thick cell coat: thin section and label fracture immunocytochemistry survey.

Authors:  P F Pimenta; P P da Silva; T Nash
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

9.  Increased expression of the molecular chaperone BiP/GRP78 during the differentiation of a primitive eukaryote.

Authors:  H D Luján; M R Mowatt; J T Conrad; T E Nash
Journal:  Biol Cell       Date:  1996       Impact factor: 4.458

10.  Identification of a novel Giardia lamblia cyst wall protein with leucine-rich repeats. Implications for secretory granule formation and protein assembly into the cyst wall.

Authors:  H D Luján; M R Mowatt; J T Conrad; B Bowers; T E Nash
Journal:  J Biol Chem       Date:  1995-12-08       Impact factor: 5.157
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  7 in total

1.  Disruption of antigenic variation is crucial for effective parasite vaccine.

Authors:  Fernando D Rivero; Alicia Saura; Cesar G Prucca; Pedro G Carranza; Alessandro Torri; Hugo D Lujan
Journal:  Nat Med       Date:  2010-04-25       Impact factor: 53.440

2.  The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolution.

Authors:  Rodney D Adam; Anuranjini Nigam; Vishwas Seshadri; Craig A Martens; Gregory A Farneth; Hilary G Morrison; Theodore E Nash; Stephen F Porcella; Rima Patel
Journal:  BMC Genomics       Date:  2010-07-09       Impact factor: 3.969

3.  Ubiquitination dynamics in the early-branching eukaryote Giardia intestinalis.

Authors:  Carlos A Niño; Jenny Chaparro; Paolo Soffientini; Simona Polo; Moises Wasserman
Journal:  Microbiologyopen       Date:  2013-04-23       Impact factor: 3.139

4.  Identification of Giardia lamblia DHHC proteins and the role of protein S-palmitoylation in the encystation process.

Authors:  María C Merino; Nahuel Zamponi; Cecilia V Vranych; María C Touz; Andrea S Rópolo
Journal:  PLoS Negl Trop Dis       Date:  2014-07-24

5.  Comparative proteomics of three Giardia lamblia strains: investigation of antigenic variation in the post-genomic era.

Authors:  Joachim Müller; Sophie Braga; Anne-Christine Uldry; Manfred Heller; Norbert Müller
Journal:  Parasitology       Date:  2020-04-27       Impact factor: 3.234

Review 6.  Membrane-Associated Proteins in Giardia lamblia.

Authors:  María C Touz; Constanza Feliziani; Andrea S Rópolo
Journal:  Genes (Basel)       Date:  2018-08-10       Impact factor: 4.096

7.  Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins.

Authors:  Marianela C Serradell; Lucía L Rupil; Román A Martino; César G Prucca; Pedro G Carranza; Alicia Saura; Elmer A Fernández; Pablo R Gargantini; Albano H Tenaglia; Juan P Petiti; Renata R Tonelli; Nicolás Reinoso-Vizcaino; José Echenique; Luciana Berod; Eliane Piaggio; Bertrand Bellier; Tim Sparwasser; David Klatzmann; Hugo D Luján
Journal:  Nat Commun       Date:  2019-01-21       Impact factor: 14.919
  7 in total

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