| Literature DB >> 12183534 |
Denis Martin1, Stéphane Rioux, Edith Gagnon, Martine Boyer, Josée Hamel, Nathalie Charland, Bernard R Brodeur.
Abstract
The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections.Entities:
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Year: 2002 PMID: 12183534 PMCID: PMC128249 DOI: 10.1128/IAI.70.9.4897-4901.2002
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441