Literature DB >> 12183534

Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein.

Denis Martin1, Stéphane Rioux, Edith Gagnon, Martine Boyer, Josée Hamel, Nathalie Charland, Bernard R Brodeur.   

Abstract

The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the production of specific antibodies that also confer protection to the newborn pups against GBS strains of serotypes Ia/c, Ib, II, III, and V. These data confirm that Sip-specific antibodies can cross the placenta and conferred protective immunity against GBS infections.

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Year:  2002        PMID: 12183534      PMCID: PMC128249          DOI: 10.1128/IAI.70.9.4897-4901.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  31 in total

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