Literature DB >> 12183057

Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts.

Akira Andoh1, Mitsue Shimada, Shigeki Bamba, Takafumi Okuno, Yoshio Araki, Yoshihide Fujiyama, Tadao Bamba.   

Abstract

In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha-induced IL-6 secretion through the induction of IL-6 mRNA stabilization. Induced stability of IL-6 mRNA was markedly decreased by the inhibitors of extracellular signal-regulated kinase (ERKs), PD98059 and U0216. This indicates that activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha.

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Year:  2002        PMID： 12183057     DOI： 10.1016/s0167-4889(02)00250-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  11 in total

Review 1.  Regulation and function of IL-17A- and IL-22-producing γδ T cells.

Authors:  Kristin J Ness-Schwickerath; Craig T Morita
Journal:  Cell Mol Life Sci       Date:  2011-05-15       Impact factor: 9.261

2.  Involvement of interleukin-17A in pancreatic damage in rat experimental acute necrotizing pancreatitis.

Authors:  Jianbo Ni; Guoyong Hu; Jie Xiong; Jie Shen; Jiaqing Shen; Lijuan Yang; Maochun Tang; Yan Zhao; Guojian Ying; Ge Yu; Yanling Hu; Miao Xing; Rong Wan; Xingpeng Wang
Journal:  Inflammation       Date:  2013-02       Impact factor: 4.092

3.  Synergistic effect of interleukin-17 and tumour necrosis factor-α on inflammatory response in hepatocytes through interleukin-6-dependent and independent pathways.

Authors:  A Beringer; N Thiam; J Molle; B Bartosch; P Miossec
Journal:  Clin Exp Immunol       Date:  2018-05-31       Impact factor: 4.330

4.  Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2.

Authors:  Fei Gao; Kelly A Brant; Rachel M Ward; Richard T Cattley; Aaron Barchowsky; James P Fabisiak
Journal:  Toxicol Appl Pharmacol       Date:  2010-06-17       Impact factor: 4.219

5.  IL-17-induced NF-kappaB activation via CIKS/Act1: physiologic significance and signaling mechanisms.

Authors:  Søren Ulrik Sønder; Sun Saret; Wanhu Tang; Dan E Sturdevant; Stephen F Porcella; Ulrich Siebenlist
Journal:  J Biol Chem       Date:  2011-02-18       Impact factor: 5.157

Review 6.  Maternal IL-17A in autism.

Authors:  Helen Wong; Charles Hoeffer
Journal:  Exp Neurol       Date:  2017-04-25       Impact factor: 5.330

7.  Interleukin-32 expression in the pancreas.

Authors:  Atsushi Nishida; Akira Andoh; Osamu Inatomi; Yoshihide Fujiyama
Journal:  J Biol Chem       Date:  2009-04-21       Impact factor: 5.157

8.  Control of early Theiler's murine encephalomyelitis virus replication in macrophages by interleukin-6 occurs in conjunction with STAT1 activation and nitric oxide production.

Authors:  Tyler C Moore; Katherine L Bush; Liz Cody; Deborah M Brown; Thomas M Petro
Journal:  J Virol       Date:  2012-07-25       Impact factor: 5.103

9.  Evaluation of Serum Interleukin-17 (IL-17) Levels as a Diagnostic Marker in Pancreatic Adenocarcinoma.

Authors:  Senem Karabulut; Çiğdem Usul Afsar; Mehmet Karabulut; Halil Alış; Leyla Kılıc; Murat Çikot; Ceren Tilgen Yasasever; Nuri Faruk Aykan
Journal:  J Gastrointest Cancer       Date:  2016-03

10.  Isolation and culture of fibroblasts from endoscopic duodenal biopsies of celiac patients.

Authors:  Leda Roncoroni; Luca Elli; Luisa Doneda; Luca Piodi; Michele M Ciulla; Roberta Paliotti; Maria Teresa Bardella
Journal:  J Transl Med       Date:  2009-06-04       Impact factor: 5.531
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