| Literature DB >> 12182879 |
Craig R Woods1, Nicolas Faucher, Bernd Eschgfaller, Kenneth W Bair, Dale L Boger.
Abstract
A series of saturated heterocyclic analogues of distamycin were prepared and examined. A fluorescent intercalator displacement (FID) assay conducted on p[dA]-p[dT] DNA to obtain C(50) values and a hairpin deoxyoligonucleotide containing an A/T-rich binding site was used to evaluate DNA binding affinity. It is observed that saturated heterocycles greatly reduce the DNA binding relative to distamycin.Entities:
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Year: 2002 PMID： 12182879 DOI： 10.1016/s0960-894x(02)00467-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823