Literature DB >> 12182873

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.

Emmanuel Pinard1, Alexander Alanine, Anne Bourson, Bernd Büttelmann, Marie Heitz, Vincent Mutela Ramanjit Gill, Gerhard Trube, René Wyler.   

Abstract

Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.

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Year:  2002        PMID： 12182873     DOI： 10.1016/s0960-894x(02)00470-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Ionotropic and metabotropic glutamate receptor structure and pharmacology.

Authors:  James N C Kew; John A Kemp
Journal:  Psychopharmacology (Berl)       Date:  2005-02-25       Impact factor: 4.530

2.  Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.

Authors:  Mark E Layton; Michael J Kelly; Kevin J Rodzinak; Philip E Sanderson; Steven D Young; Rodney A Bednar; Anthony G Dilella; Terrence P McDonald; Hao Wang; Scott D Mosser; John F Fay; Michael E Cunningham; Duane R Reiss; Christine Fandozzi; Nicole Trainor; Annie Liang; Edward V Lis; Guy R Seabrook; Mark O Urban; James Yergey; Kenneth S Koblan
Journal:  ACS Chem Neurosci       Date:  2011-04-15       Impact factor: 4.418

3.  Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor.

Authors:  X-K Wee; K-S Ng; H-W Leung; Y-P Cheong; K-H Kong; F-M Ng; W Soh; Y Lam; C-M Low
Journal:  Br J Pharmacol       Date:  2010-01-15       Impact factor: 8.739

4.  Direct one-pot synthesis of primary 4-amino-2,3-diaryl-quinolines via Suzuki-Miyaura cross-coupling of 2-aryl-4-azido-3-iodoquinolines with arylboronic acids.

Authors:  Malose Jack Mphahlele; Mamasegare Mabel Mphahlele
Journal:  Molecules       Date:  2011-10-25       Impact factor: 4.411

5.  One-pot synthesis of 2,3,4-triarylquinolines via suzuki-miyaura cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with arylboronic acids.

Authors:  Malose Jack Mphahlele; Mamasegare Mabel Mphahlele
Journal:  Molecules       Date:  2010-10-22       Impact factor: 4.411
  5 in total

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