Literature DB >> 12182867

DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria.

Roland W Bürli1, Yigong Ge, Sarah White, Eldon E Baird, Sofia M Touami, Matthew Taylor, Jacob A Kaizerman, Heinz E Moser.   

Abstract

An efficient synthesis of DNA binding molecules consisting of four heterocyclic carboxamide units and various substituents at both termini is described. The minor-groove binding ligands showed excellent activity against a broad range of Gram-positive bacteria; no cross-resistance to known antibacterial drugs was observed.

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Year:  2002        PMID： 12182867     DOI： 10.1016/s0960-894x(02)00515-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Polyhalonitrobutadienes as Versatile Building Blocks for the Biotargeted Synthesis of Substituted N-Heterocyclic Compounds.

Authors:  Viktor A Zapol'skii; Ursula Bilitewski; Sören R Kupiec; Isabell Ramming; Dieter E Kaufmann
Journal:  Molecules       Date:  2020-06-21       Impact factor: 4.411

2.  Solution-phase synthesis of a tricyclic pyrrole-2-carboxamide discovery library applying a stetter-Paal-Knorr reaction sequence.

Authors:  Stefan Werner; Pravin S Iyer; Matthew D Fodor; Claire M Coleman; Leslie A Twining; Branko Mitasev; Kay M Brummond
Journal:  J Comb Chem       Date:  2006 May-Jun

3.  Pharmacology of novel heteroaromatic polycycle antibacterials.

Authors:  M Gross; R Bürli; P Jones; M Garcia; B Batiste; J Kaizerman; H Moser; V Jiang; U Hoch; J-X Duan; R Tanaka; K W Johnson
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

4.  Chemistry of polyhalogenated nitrobutadienes, 10: Synthesis of highly functionalized heterocycles with a rigid 6-amino-3-azabicyclo[3.1.0]hexane moiety.

Authors:  Viktor A Zapol'skii; Jan C Namyslo; Armin de Meijere; Dieter E Kaufmann
Journal:  Beilstein J Org Chem       Date:  2012-04-23       Impact factor: 2.883
  4 in total

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