| Literature DB >> 12182865 |
M Gallant1, M C Carrière, A Chateauneuf, D Denis, Y Gareau, C Godbout, G Greig, H Juteau, N Lachance, P Lacombe, S Lamontagne, K M Metters, C Rochette, R Ruel, D Slipetz, N Sawyer, N Tremblay, M Labelle.
Abstract
Potent and selective ligands for the human EP3 prostanoid receptor are described. Biaryl compounds bearing a tethered ortho substituted acidic moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinity of key compounds on all eight human prostanoid receptors is reported.Entities:
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Year: 2002 PMID： 12182865 DOI： 10.1016/s0960-894x(02)00518-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823