Literature DB >> 12182861

Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.

John K Clark1, Phill Cowley, Alan W Muir, Ronald Palin, Eleanor Pow, Alan B Prosser, Robert Taylor, Ming-Qiang Zhang.   

Abstract

A series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of neuromuscular block induced by vecuronium. Several potent reversal agents have been identified and their haemodynamic effects measured.

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Year:  2002        PMID: 12182861     DOI: 10.1016/s0960-894x(02)00482-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.

Authors:  Carles Galdeano; Nicolas Coquelle; Monika Cieslikiewicz-Bouet; Manuela Bartolini; Belén Pérez; M Victòria Clos; Israel Silman; Ludovic Jean; Jacques-Philippe Colletier; Pierre-Yves Renard; Diego Muñoz-Torrero
Journal:  Molecules       Date:  2018-03-11       Impact factor: 4.411

  1 in total

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