| Literature DB >> 12182856 |
Charles Q Meng1, Patricia K Somers, Carolyn L Rachita, Lisa A Holt, Lee K Hoong, X Sharon Zheng, Jacob E Simpson, Russell R Hill, Lynda K Olliff, Charles Kunsch, Cynthia L Sundell, Sampath Parthasarathy, Uday Saxena, James A Sikorski, Martin A Wasserman.
Abstract
A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-alpha-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunctional agents led to the identification of 3a (AGI-1067) as a clinical candidate with demonstrated efficacies in animal models of atherosclerosis and hyperlipidemia.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12182856 DOI： 10.1016/s0960-894x(02)00516-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823