| Literature DB >> 12182622 |
Kenneth G Holden1, Matthew N Mattson, Kyung Hoi Cha, Henry Rapoport.
Abstract
The synthesis of a chiral pilocarpine analogue 3 in which the lactone ring is replaced by an oxazolidinone and the bridging methylene group is in the ketone oxidation state has been accomplished. The utility of this compound as a key intermediate for the preparation of more complex structures was demonstrated by its reduction to two alcohol epimers and its reaction with a methylene ylide.Entities:
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Year: 2002 PMID： 12182622 DOI： 10.1021/jo0111210
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354