Literature DB >> 12182597

A divergent approach to the myriaporones and tedanolide: completion of the carbon skeleton of myriaporone 1.

Richard E Taylor1, Brian R Hearn, Jeffrey P Ciavarri.   

Abstract

[reaction: see text] A linear but concise synthetic approach toward the structurally related natural products myriaporone and tedanolide is reported. The route is highlighted by a stereoselective homoallenylboration and a regio- and chemoselective nitrile oxide cycloaddition. Installation of the (Z)-olefin completed the carbon skeleton of myriaporone 1.

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Year:  2002        PMID： 12182597     DOI： 10.1021/ol026356s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Total syntheses of (+)-tedanolide and (+)-13-deoxytedanolide.

Authors:  Joshua R Dunetz; Lisa D Julian; Jason S Newcom; William R Roush
Journal:  J Am Chem Soc       Date:  2008-12-03       Impact factor: 15.419

2.  A unified approach to the tedanolides: total synthesis of (+)-13-deoxytedanolide.

Authors:  Amos B Smith; Christopher M Adams; Stephanie A Lodise Barbosa; Andrew P Degnan
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-26       Impact factor: 11.205
  2 in total

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