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Literature DB >> 12181643

906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDHs) in the Japanese population.

Susumu Saito¹, Aritoshi Iida, Akihiro Sekine, Chie Ogawa, Saori Kawauchi, Shoko Higuchi, Machi Ohno, Yusuke Nakamura.

Abstract

We screened DNAs from 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in genes encoding 13 cytochrome P450 (CYP) enzymes and 14 aldehyde dehydrogenases (ALDHs) by directly sequencing their entire genomic regions except for repetitive elements. This approach identified 810 SNPs and 96 insertion/deletion polymorphisms among the 27 genes. Of the 810 SNPs, 229 were identified among the CYP genes and 581 in the ALDH genes; of the total, 48 SNPs were located in 5' flanking regions, 619 in introns, 91 in exons, and 52 in 3' flanking regions. These variants should contribute to studies designed to investigate possible correlations between genotypes and phenotypes of disease susceptibility or responsiveness to drug therapy.

Entities: Gene

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Year: 2002 PMID： 12181643 DOI： 10.1007/s100380200061

Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172

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Cited

8 in total

1. Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus.

Authors: Aritoshi Iida; Susumu Saito; Akihiro Sekine; Wataru Tabei; Yukie Kataoka; Yusuke Nakamura
Journal: J Hum Genet Date: 2004-06-18 Impact factor: 3.172

2. Inference from the relationships between linkage disequilibrium and allele frequency distributions of 240 candidate SNPs in 109 drug-related genes in four Asian populations.

Authors: Pei-Chieng Cha; Ryo Yamada; Akihiro Sekine; Yusuke Nakamura; Chong-Lek Koh
Journal: J Hum Genet Date: 2004-09-11 Impact factor: 3.172

3. Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors.

Authors: Aritoshi Iida; Susumu Saito; Akihiro Sekine; Yukie Kataoka; Wataru Tabei; Yusuke Nakamura
Journal: J Hum Genet Date: 2004-03-20 Impact factor: 3.172

4. Identification of 156 novel SNPs in 29 genes encoding G-protein coupled receptors.

Authors: Aritoshi Iida; Yusuke Nakamura
Journal: J Hum Genet Date: 2005-04-12 Impact factor: 3.172

5. SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions.

Authors: Paola Blasi; Francesca Palmerio; Aurora Aiello; Mariano Rocchi; Patrizia Malaspina; Andrea Novelletto
Journal: J Mol Evol Date: 2006-06-17 Impact factor: 2.395

906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDHs) in the Japanese population.

1. Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus.

2. Inference from the relationships between linkage disequilibrium and allele frequency distributions of 240 candidate SNPs in 109 drug-related genes in four Asian populations.

3. Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors.

4. Identification of 156 novel SNPs in 29 genes encoding G-protein coupled receptors.

5. SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions.

6. Mutation and protein expression analysis of CYP1A1 gene-a study on female breast cancer cases from India.

7. Mutational analysis of xenobiotic metabolizing genes (CYP1A1 and GSTP1) in sporadic head and neck cancer patients.

8. Association of the G134A and G184C Polymorphisms in the CYP1A1 Gene with Lung Cancer Incidence.