Literature DB >> 12180966

Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis.

Leighton Pritchard1, Douglas B Kell.   

Abstract

We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.

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Year:  2002        PMID： 12180966     DOI： 10.1046/j.1432-1033.2002.03055.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  19 in total

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