OBJECTIVE: To examine the effect of methotrexate (MTX) and folic acid supplementation on the homocysteine level in patients with rheumatoid arthritis (RA). METHODS: A cross sectional study was performed in 81 patients with RA, comprising a standardized clinical interview, an examination, and a blood specimen test. RESULTS: P-homocysteine tended to be lower in 41 patients receiving MTX, compared with 40 patients not receiving MTX. Of the MTX treated patients, 76% received folic acid supplementation. Multivariate analysis revealed a statistically significant association between P-homocysteine and P-creatinine (p < 0.001), and disease activity/progression measured by the Health Assessment Questionnaire score (p < 0.001). There was a tendency to negative association between P-homocys-teine and folic acid supplementation. CONCLUSION: P-homocysteine in patients with RA receiving MTX and folic acid supplementation did not differ significantly from P-homocysteine in RA patients receiving other types of treatment.
OBJECTIVE: To examine the effect of methotrexate (MTX) and folic acid supplementation on the homocysteine level in patients with rheumatoid arthritis (RA). METHODS: A cross sectional study was performed in 81 patients with RA, comprising a standardized clinical interview, an examination, and a blood specimen test. RESULTS:P-homocysteine tended to be lower in 41 patients receiving MTX, compared with 40 patients not receiving MTX. Of the MTX treated patients, 76% received folic acid supplementation. Multivariate analysis revealed a statistically significant association between P-homocysteine and P-creatinine (p < 0.001), and disease activity/progression measured by the Health Assessment Questionnaire score (p < 0.001). There was a tendency to negative association between P-homocys-teine and folic acid supplementation. CONCLUSION:P-homocysteine in patients with RA receiving MTX and folic acid supplementation did not differ significantly from P-homocysteine in RApatients receiving other types of treatment.
Authors: Refael Segal; Yehuda Baumoehl; Ori Elkayam; David Levartovsky; Irena Litinsky; Daphna Paran; Irena Wigler; Beni Habot; Arthur Leibovitz; Ben Ami Sela; Dan Caspi Journal: Rheumatol Int Date: 2003-04-29 Impact factor: 2.631
Authors: Y Berkun; D Levartovsky; A Rubinow; H Orbach; S Aamar; T Grenader; I Abou Atta; D Mevorach; G Friedman; A Ben-Yehuda Journal: Ann Rheum Dis Date: 2004-10 Impact factor: 19.103
Authors: Laura Gonzalez-Lopez; Julia D Sanchez-Hernandez; Erika A G Aguilar-Chavez; Adolfo R Cota-Sanchez; Maria A Lopez-Olivo; Alberto I Villa-Manzano; Ricardo Ortega-Flores; Genadia L Espinoza-Magaña; Wendoline Rojo-Contreras; Ernesto G Cardona-Muñoz; Jorge I Gamez-Nava Journal: Rheumatol Int Date: 2008-08-22 Impact factor: 2.631