| Literature DB >> 12180479 |
Gokhan Demir1, Sedef Belentepe, Mustafa Ozguroglu, Aykut Ferhat Celik, Nur Sayhan, Salim Tekin, Nil Molinas Mandel, Evin Buyukunal, Suheyla Serdengecti.
Abstract
Family history and hepatitis B virus (HBV) infection have been identified as risk factors for hepatocellular carcinoma. We report hepatocellular carcinoma (HCC) diagnosed at the same time in identical twin brothers. Serological analyses of the patients showed that both were chronically infected with HBV. Molecular analyses of the tumor specimens confirmed loss of heterozygocity of the Rb gene region. Both of the patients were unresponsive to chemotherapy and died within the same month with an interval of I wk. With a review of the current literature, we discuss the role of HBV infection and genetic factors on hepatic carcinogenesis.Entities:
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Year: 2002 PMID： 12180479 DOI： 10.1385/MO:19:2:113
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064