PURPOSE: To assess whether interactions of common alleles of two folate genes contribute to spina bifida risk. METHODS: Case-control study, comparing 203 children with spina bifida to 583 controls. RESULTS: Homozygosity for the 677C-T allele of 5,10-methylenetetrahydrofolate reductase (MTHFR) alone was associated with an odds ratio for spina bifida of 1.57 (95% confidence interval [CI], 1.02-2.38). For the 844ins68 allele of cystathionine-beta-synthase alone, the odds ratio was 0.83 (95% CI, 0.39-1.64). For the joint genotype, the odds ratio was 3.69 (95% CI, 1.04-13.50). CONCLUSIONS: Interactions between common alleles of folate genes might contribute to the risk for spina bifida.
PURPOSE: To assess whether interactions of common alleles of two folate genes contribute to spina bifida risk. METHODS: Case-control study, comparing 203 children with spina bifida to 583 controls. RESULTS: Homozygosity for the 677C-T allele of 5,10-methylenetetrahydrofolate reductase (MTHFR) alone was associated with an odds ratio for spina bifida of 1.57 (95% confidence interval [CI], 1.02-2.38). For the 844ins68 allele of cystathionine-beta-synthase alone, the odds ratio was 0.83 (95% CI, 0.39-1.64). For the joint genotype, the odds ratio was 3.69 (95% CI, 1.04-13.50). CONCLUSIONS: Interactions between common alleles of folate genes might contribute to the risk for spina bifida.
Authors: Liina Pappa; Mart Kals; Paula Ann Kivistik; Andres Metspalu; Ann Paal; Tiit Nikopensius Journal: Childs Nerv Syst Date: 2017-07-18 Impact factor: 1.475
Authors: Carla A Martinez; Hope Northrup; Jone-Ing Lin; Alanna C Morrison; Jack M Fletcher; Gayle H Tyerman; Kit Sing Au Journal: Am J Obstet Gynecol Date: 2009-08-15 Impact factor: 8.661
Authors: Xiang-Yang Lou; Ting-Ting Hou; Shou-Ye Liu; Hai-Ming Xu; Feng Lin; Xinyu Tang; Stewart L MacLeod; Mario A Cleves; Charlotte A Hobbs Journal: Genet Epidemiol Date: 2020-09-30 Impact factor: 2.344