| Literature DB >> 12177685 |
Robert Hoerr1, Michael Noeldner.
Abstract
Ensaculin, a novel benzopyranone substituted with a piperazine moiety, showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effects in primary cultured rat brain cells. The compound could be characterized as a weak NMDA receptor-operated channel blocker. In receptor-binding studies, ensaculin was found to have high affinities to serotonergic 5-HT(1A) and 5-HT(7) receptors, adrenergic alpha(1), and dopaminergic D(2) and D(3) receptors. Due to its unique pharmacodynamic profile, ensaculin may have potential as an antidementia agent acting on various transmitter systems.Entities:
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Year: 2002 PMID： 12177685 PMCID： PMC6741668 DOI： 10.1111/j.1527-3458.2002.tb00220.x
Source DB: PubMed Journal: CNS Drug Rev ISSN： 1080-563X