Literature DB >> 12177507

The two hats of SOS.

Anjaruwee Nimnual1, Dafna Bar-Sagi.   

Abstract

Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be recruited to different cellular locations through interactions with the adaptor proteins Grb2 and E3b1.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12177507     DOI： 10.1126/stke.2002.145.pe36

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  40 in total

1.  Noonan syndrome: clinical aspects and molecular pathogenesis.

Authors:  M Tartaglia; G Zampino; B D Gelb
Journal:  Mol Syndromol       Date:  2010-01-15

Review 2.  How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization.

Authors:  Ethan J Brock; Kyungmin Ji; John J Reiners; Raymond R Mattingly
Journal:  Mini Rev Med Chem       Date:  2016       Impact factor: 3.862

3.  Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.

Authors:  Kazuhiro Aoki; Takeshi Nakamura; Keiko Fujikawa; Michiyuki Matsuda
Journal:  Mol Biol Cell       Date:  2005-02-23       Impact factor: 4.138

4.  Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.

Authors:  Peng-Chieh Chen; Hiroko Wakimoto; David Conner; Toshiyuki Araki; Tao Yuan; Amy Roberts; Christine E Seidman; Roderick Bronson; Benjamin G Neel; Jonathan G Seidman; Raju Kucherlapati
Journal:  J Clin Invest       Date:  2010-12       Impact factor: 14.808

Review 5.  Tumor adaptation and resistance to RAF inhibitors.

Authors:  Piro Lito; Neal Rosen; David B Solit
Journal:  Nat Med       Date:  2013-11       Impact factor: 53.440

6.  Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.

Authors:  Emanuele Giurisato; Marina Cella; Toshiyuki Takai; Tomohiro Kurosaki; Yungfeng Feng; Gregory D Longmore; Marco Colonna; Andrey S Shaw
Journal:  Mol Cell Biol       Date:  2007-10-08       Impact factor: 4.272

7.  Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.

Authors:  Junji Yamauchi; Yuki Miyamoto; Akito Tanoue; Eric M Shooter; Jonah R Chan
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-03       Impact factor: 11.205

8.  Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.

Authors:  Caleb B McDonald; Kenneth L Seldeen; Brian J Deegan; Vikas Bhat; Amjad Farooq
Journal:  Arch Biochem Biophys       Date:  2009-12-22       Impact factor: 4.013

9.  Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Authors:  Jesse E Jun; Ming Yang; Hang Chen; Arup K Chakraborty; Jeroen P Roose
Journal:  Mol Cell Biol       Date:  2013-04-15       Impact factor: 4.272

10.  Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.

Authors:  Caleb B McDonald; Vikas Bhat; Dmitry Kurouski; David C Mikles; Brian J Deegan; Kenneth L Seldeen; Igor K Lednev; Amjad Farooq
Journal:  Biophys Chem       Date:  2013-03-05       Impact factor: 2.352
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.