| Literature DB >> 12177384 |
Sarah J Augood1, Z Hollingsworth, D S Albers, L Yang, J-C Leung, B Muller, C Klein, X O Breakefield, D G Standaert.
Abstract
Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D(1) receptor and D(2) receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12177384 DOI： 10.1212/wnl.59.3.445
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910