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Literature DB >> 12177295

Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast.

Emmanuelle Fabre¹, Bernard Dujon, Guy-Franck Richard.

Abstract

Trinucleotide repeats are involved in several neurological disorders in humans. DNA sequences containing CAG/CTG repeats are prone to slippage during replication and double-strand break repair. The effects of trinucleotide repeats on transcription and on nuclear export were analyzed in vivo in yeast. Transcription of a CAG/CTG trinucleotide repeat in the 3'-untranslated region of a URA3 reporter gene leads to transcription of messenger RNAs several kilobases longer than the expected size. These long mRNAs form more readily when CAG rather than CTG repeats are transcribed. CAG- or CUG-containing transcripts show a non-homogeneous cellular localization. We propose that long mRNAs result from transcription slippage, and discuss the possible implications for human diseases.

Entities: Chemical Disease Gene Species

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Year: 2002 PMID： 12177295 PMCID： PMC134249 DOI： 10.1093/nar/gkf483

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

40 in total

1. Amino acid reiterations in yeast are overrepresented in particular classes of proteins and show evidence of a slippage-like mutational process.

Authors: M Mar Albà; M F Santibáñez-Koref; J M Hancock
Journal: J Mol Evol Date: 1999-12 Impact factor: 2.395

2. Effect of the higher-order structure of tRNAs on the stability of hybrids with oligodeoxyribonucleotides: separation of tRNA by an efficient solution hybridization.

Authors: Y Kumazawa; T Yokogawa; H Tsurui; K Miura; K Watanabe
Journal: Nucleic Acids Res Date: 1992-05-11 Impact factor: 16.971

3. Transcriptional slippage during the transcription initiation process at a mutant lac promoter in vivo.

Authors: X F Xiong; W S Reznikoff
Journal: J Mol Biol Date: 1993-06-05 Impact factor: 5.469

4. Termination and slippage by bacteriophage T7 RNA polymerase.

Authors: L E Macdonald; Y Zhou; W T McAllister
Journal: J Mol Biol Date: 1993-08-20 Impact factor: 5.469

Review 5. Evolution and consequences of transposable elements.

Authors: J F McDonald
Journal: Curr Opin Genet Dev Date: 1993-12 Impact factor: 5.578

6. Topology of the product binding site in RNA polymerase revealed by transcript slippage at the phage lambda PL promoter.

Authors: K Severinov; A Goldfarb
Journal: J Biol Chem Date: 1994-12-16 Impact factor: 5.157

7. Transcript map of two regions from chromosome XI of Saccharomyces cerevisiae for interpretation of systematic sequencing results.

Authors: C Fairhead; B Dujon
Journal: Yeast Date: 1994-11 Impact factor: 3.239

8. Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy.

Authors: H G Harley; J D Brook; S A Rundle; S Crow; W Reardon; A J Buckler; P S Harper; D E Housman; D J Shaw
Journal: Nature Date: 1992-02-06 Impact factor: 49.962

9. Hairpin properties of single-stranded DNA containing a GC-rich triplet repeat: (CTG)15.

Authors: M Mitas; A Yu; J Dill; T J Kamp; E J Chambers; I S Haworth
Journal: Nucleic Acids Res Date: 1995-03-25 Impact factor: 16.971

10. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

Authors: J D Brook; M E McCurrach; H G Harley; A J Buckler; D Church; H Aburatani; K Hunter; V P Stanton; J P Thirion; T Hudson
Journal: Cell Date: 1992-02-21 Impact factor: 41.582

8 in total

1. Evolutionary patterns of non-coding RNAs.

Authors: Athanasius F Bompfünewerer; Christoph Flamm; Claudia Fried; Guido Fritzsch; Ivo L Hofacker; Jörg Lehmann; Kristin Missal; Axel Mosig; Bettina Müller; Sonja J Prohaska; Bärbel M R Stadler; Peter F Stadler; Andrea Tanzer; Stefan Washietl; Christina Witwer
Journal: Theory Biosci Date: 2005-04 Impact factor: 1.919

Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast.

1. Amino acid reiterations in yeast are overrepresented in particular classes of proteins and show evidence of a slippage-like mutational process.

2. Effect of the higher-order structure of tRNAs on the stability of hybrids with oligodeoxyribonucleotides: separation of tRNA by an efficient solution hybridization.

3. Transcriptional slippage during the transcription initiation process at a mutant lac promoter in vivo.

4. Termination and slippage by bacteriophage T7 RNA polymerase.

Review 5. Evolution and consequences of transposable elements.

6. Topology of the product binding site in RNA polymerase revealed by transcript slippage at the phage lambda PL promoter.

7. Transcript map of two regions from chromosome XI of Saccharomyces cerevisiae for interpretation of systematic sequencing results.

8. Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy.

9. Hairpin properties of single-stranded DNA containing a GC-rich triplet repeat: (CTG)15.

10. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

1. Evolutionary patterns of non-coding RNAs.

Review 2. Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.

3. Short homologous sequences are strongly associated with the generation of chimeric RNAs in eukaryotes.

4. A genomic portrait of human microsatellite variation.

Review 5. Regulation of gene expression by reiterative transcription.

6. Trinucleotide repeats in human genome and exome.

7. The (CAG)n tract of Machado-Joseph Disease gene (ATXN3): a comparison between DNA and mRNA in patients and controls.

8. Evolution of coding microsatellites in primate genomes.